منابع مشابه
Ubiquitin interactions of NZF zinc fingers.
Ubiquitin (Ub) functions in many different biological pathways, where it typically interacts with proteins that contain modular Ub recognition domains. One such recognition domain is the Npl4 zinc finger (NZF), a compact zinc-binding module found in many proteins that function in Ub-dependent processes. We now report the solution structure of the NZF domain from Npl4 in complex with Ub. The str...
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The multifactorial etiology of atherosclerosis includes inflammatory and immune processes that involve numerous cell types, including monocytic and lymphocytic leukocytes, endothelial cells, smooth muscle cells, and fibroblasts. It is likely that each of these cell types, as a contributor to the atherosclerotic process, possesses a gene expression profile unique to its role in disease pathogene...
متن کاملZinc Fingers Function Cooperatively with KRAB Domain for Nuclear Localization of KRAB-Containing Zinc Finger Proteins
Multiple nuclear localization domains have been identified in nuclear proteins, and they finely control nuclear import and functions of those proteins. ZNF268 is a typical KRAB-containing zinc finger protein (KRAB-ZFP), and previous studies have shown that the KRAB domain reinforces nuclear localization of KRAB-ZFPs by interacting with KAP1. In this study, we find that some of 24 zinc fingers o...
متن کاملZinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains.
We now recognize three distinct motifs of DNA-binding zinc proteins: (i) zinc fingers, (ii) zinc clusters, and (iii) zinc twists. Until very recently, x-ray crystallographic or NMR three-dimensional structure analyses of DNA-binding zinc proteins have not been available to serve as standards of reference for the zinc binding sites of these families of proteins. Those of the DNA-binding domains ...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2011
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt.1749